Thank you operator. Hi, everyone. I want to begin by thanking all of you for joining us today.
While the last 12 months have been an exciting period of operational and commercial growth for OptimizeRx, we have been more excited for the year ahead as we move forward with continued momentum as a company. The major investments we have made over the last year has centered around setting up the organization for future scalable growth.
We have completed a strategic build out of OptimizeRx’s leadership team on the solutions and digital enablement front we launched several AI and data centric solutions expanding our strategic capabilities, positioning us well to focus more on the key markets including, specialty medications. And lastly, we made huge progress in building out additional reach to doctors and patients. In essence, we've invested in our three primary growth drivers to continue our organic growth trajectory. To illustrate this point and how we build customer stickiness as a technology partner to life sciences, earlier this week, we announced the launch of a large scale therapy initiation program with a top 10 pharma client. The program accelerates patient’s access to a new specialty drug that can reduce inflammation for chronic condition and significantly improve the quality of life for this previously underserved patient population. The pharma client is leveraging OptimizeRx’s suite of digital solutions to streamline therapy initiation for these patients, by ensuring that physicians have immediate electronic access to the appropriate enrollment forms needed to prescribe the medication. This is our largest enterprise scale therapy initiation program launched to date.
As the new specialty therapies continue entering a crowded market with complex requirements, and sometimes limited pharmacy distribution networks, OptimizeRx is well positioned to help life sciences get patients on therapy quickly and more efficiently.
We are very confident in our suite of solutions, and we continue to receive overwhelmingly positive client feedback. 2021 was the last year that enterprise deals remained a measure of our success, and a proxy for execution.
As an organization, we feel that we have surpassed this metric both in deal count, as well as in the overall demand for bundled solution sets.
We have put forward a new set of performance metrics against which to measure our success. Ed and Andy's leadership have been key as they hit the ground running since joining our team and lead the development of relevant key performance indicators, KPIs that best represent our land and expand strategy within key customer accounts.
As a proxy for execution, the KPIs that we introduced in advance of this call include the company's penetration within the top 20 largest pharmaceutical manufacturers, net revenue retention, and revenue per employee, which Ed will go into more detail later. From a customer capture perspective, we now serve nearly all of the top 20 large pharma manufacturers, who represent the largest portion of the industry's marketing, spend.
Our KPIs are important from this perspective, as the pharmaceutical industry is dominated by large companies with multiple brands, so our revenue is naturally going to be concentrated within these larger entities.
For example, more than three quarters of our net revenue for last year was generated through these industry bellwethers as we deepened our relationship with large pharma and their brands. We're also starting to generate more revenue per employee, which is a testament to our operational efficiency and ability to scale. And to give you an idea of the market opportunity, our footprint in the top 20 Pharma is positioning us to compete and win our share of the largest categories of addressable commercial spend, which in turn will be communicated in a transparent and measurable fashion. This focus on penetration and capturing a large share of wallet within Pharma is going to be a strategic imperative for 2022 and a core to our ability to grow revenues while meeting or exceeding our financial targets.
As a baseline, we believe that our total addressable market for digital enabled solution is in the billions of dollars. Based on that, we estimate that we have captured less than 5% of this rapidly emerging market, making us confident our growth will continue. This year, we've been even more focused on helping life science companies leverage the power and reach of our platforms technology.
We are helping them bring therapeutic awareness to both patients and providers, and just as importantly, assisting patients to start and stay on life impacting therapies.
As a healthcare technology company, we are thrilled with the opportunity to positively affect therapeutic outcomes through the application of modern data practices, and AI driven solutions throughout the patient journey at the point of care. In that spirit, the fact is that there is a vast industry whitespace standing before us that is yet to be charted.
As we progress through 2022, we will continue leveraging our team's domain expertise and our capabilities as a leading health technology company enabling engagement between life science organizations, healthcare providers, and patients during critical junctures throughout the patient journey. What this translates to is doing a great job on behalf of our clients; digitally bridging the gap between life science organizations, patients and providers all while staying in strict compliance of all regulatory requirements. Like many other industries, healthcare is undergoing a digital evolution, striving to adapt to the constant pressure of digitization and the prevailing use of mobile and digital devices and other technologies.
We are facilitating the digital evolution for life science organizations, being the technology solutions that our clients require to move forward in this arena so that they won't have to go it alone. Industry evolution is one of the reasons we view our platforms adoption as still very early on the S curve, despite the strong growth we've been able to demonstrate since our refounding in 2016.
Our product demand and brand penetration is also rising among our customers, as they see the value of the platform's ability to meet their digital engagement needs. The fact that our enterprise engagements provide a precise measurable return on investment against their marketing spend is key. This performance measurement will continue to be a key theme for the remainder of 2022.
Before we talk about this further, I just want to mention again that we have spent the last several years configuring our platform for scalability, including establishing a technology center of excellence in Croatia.
As scalability can be a major impediment for growth, we made the decision to take care of this early on.
So we are now able to focus our attention solely on efficient and rapid market expansion, and the growing digitization of the healthcare industry at large. In 2021, we brought together a terrific group of data scientists to help with the build out of our innovative digital solutions. That set of solutions now includes a full suite focused specifically on the deployment of AI, artificial intelligence, and data analytics live at the point-of-care to provide physicians with real time information and support while they're making critical treatment decisions with their patients. Providing key information in real time at the point-of-care can help get a patient initiated on therapy a lot sooner. This capability is unbelievably valuable to life science companies, particularly those specialty brands, where early intervention can be the deciding factors in whether a patient will have a positive therapeutic outcome. Financially, as noted in our press release, we had yet another record year. Revenues grew 42% year-over-year to $61.3 million.
Our business is really fitting example of the whole being a greater than the sum of its parts.
Our solutions span the entire patient journey beginning at the initial point-of-care to drive better engagement and revenue growth. We do this through a single platform approach delivering everything from physician and pharma sales engagement, to personalized patient support in order to improve therapeutic outcomes. Like with many industries, right now, the data tools we are deploying have only started to come into the fold of mainstream customer and digital engagement in the last several years.
In terms of our new set of KPIs and outlook, and given our position in the market, we're really excited to take this meaningful step. We're looking forward to another strong year of growth while helping patients start and stay on life improving therapies.
Finally, before we go to our financial review with Ed, I want to remind everyone on the call that even with our focus on growth, and being in the early innings from market penetration standpoint, we generated positive cash flow from operations in 2021. And lastly, while not an official KPI our clients remain extremely pleased as we are delivering an average ROI of 13 to one. And as in other reporting quarters, some clients are experiencing much higher ROI. With that, I'd like to turn the call over to our CFO and CEO Ed Stelmakh, who will walk us through the financial details for Q4. Ed?